Visualization of Tissue Microstructure (publications) Tissue microstructure is tremendously complex, encompassing vast space-filling microvascular networks and highly interconnected neural networks.  One of the major challenges in biology is understanding the three-dimensional structure of tissue data at its highest resolution.  Even with emerging high-throughput imaging technology that allows us to capture these data sets, we are still faced with the challenge of making large and complex data sets fit for human interpretation. My current research includes: Visualizing the relationships between cells and microvessels (video) Interactive visualization of large filament networks

Knife-Edge Scanning Microscopy (publications) A major focus of my research at the Brain Networks Lab has been the development of new high-throughput imaging techniques.  In particular, we have developed a new microscopy technique, known as Knife-Edge Scanning Microscopy, which allows us to efficiently image large-scale tissue microstructure.  This technology has allowed us to image entire organs of the mouse at sub-cellular resolution, creating terabytes of high-contrast data describing some of the most complex structures ever seen. My current research includes: Modifying the KESM to use fluorescence Extensive studies of brain microvasculature (whole brain video, cerebellar microvessels video) Extensive studies of neural anatomy (Pyramidal cells video, Purkinje cells video)